Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
نویسندگان
چکیده
منابع مشابه
Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan
Idiopathic membranous nephropathy (MN) is one common cause of idiopathic nephrotic syndrome in adults; 25% of MN patients proceed to end-stage renal disease. In adults, membranous nephropathy is a lead cause of nephrotic syndrome, with about 75% of the cases idiopathic. Secondary causes include autoimmune disease, infection, drugs and malignancy. Three hypotheses about pathogenesis have surface...
متن کاملChapter 7: Idiopathic membranous nephropathy
BACKGROUND The diagnosis of MN is made on kidney biopsy. Diagnostic features include capillary wall thickening, normal cellularity, IgG and C3 along capillary walls on immunofluorescence, and subepithelial deposits on electron microscopy. MN is often seen in association with an underlying disorder (secondary MN). Secondary MN is more common in children (75%) than adults (25%) (Table 12). The di...
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Exciting progress recently has been made in our understanding of idiopathic membranous nephropathy, as well as treatment of this disease. Here, we review important advances regarding the pathogenesis of membranous nephropathy. We will also review the current approach to treatment and its limitations and will highlight new therapies that are currently being explored for this disease including Ri...
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BACKGROUND Rituximab represents a valid therapeutic option to induce remission in patients with primary glomerulonephritis. Despite several studies proving its efficacy in improving outcomes in patients with membranous nephropathy (MN), its role in therapeutic protocols is not yet defined. METHODS We studied 38 patients with idiopathic MN treated with rituximab (in 13 patients as first-line t...
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Just over 50 years ago, the late David Jones1 iden tified (using the periodic acid–Schiff and meth enamine silver stains) the unique glomerular pathologic features of membranous nephropathy, thus distinguishing it from other causes of “ne phrotic glomerulonephritis.” Subsequent immuno fluorescence and electronmicroscopical studies established that membranous nephropathy was also characteri...
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ژورنال
عنوان ژورنال: BioMedicine
سال: 2014
ISSN: 2211-8039
DOI: 10.7603/s40681-014-0009-y